Dialkylformamldines: depurination resistant N6-protecting group for deoxyadenosine

Termination of DNA synthesis by N6-alkylated, not 3′-O-alkylated, photocleavable 2′-deoxyadenosine triphosphates

The Human Genome Project has facilitated the sequencing of many species, yet the current Sanger method is too expensive, labor intensive and time consuming to accomplish medical resequencing of human genomes en masse. Of the 'next-generation' technologies, cyclic reversible termination (CRT) is a promising method with the goal of producing accurate sequence information at a fraction of the cost...

Enzymatic protecting group techniques.

The proper introduction and removal of protecting groups is one of the most important and widely carried out synthetic transformations in preparative organic chemistry. In particular, in the highly selective construction of complex, polyfunctional molecules, e.g., oligonucleotides, oligosaccharides, peptides, and conjugates thereof, and in the synthesis of alkaloids, macrolides, polyether antib...

Novel photolabile protecting group for carbonyl compounds.

[reaction: see text] A novel type of photo-protecting group for carbonyl compounds is described. The protecting group is readily accessed in one step from commercially available material. Installation of the protecting group upon the carbonyl compounds is achieved in excellent yields. The carbonyl compounds in their protected form are remarkably stable under various conditions and can be releas...

Strategies for Protecting Group Free Glycosidation

A Divalent Protecting Group for Benzoxaboroles.

1-Dimethylamino-8-methylaminonaphthalene is put forth as a protecting group for benzoxaboroles. The ensuing complex is fluorescent, charge-neutral, highly stable under basic conditions, stable to anhydrous acid, and readily cleavable in aqueous acid to return the free benzoxaborole.